PT-141 ua los ntawm kev tsom mus rau cov cheeb tsam hauv lub hlwb koom nrog kev sib deev arousal es tsis yog lub peripheral vascular system; Hauv Phase I sim no, nws tau pom tias muaj peev xwm ua kom cov ntshav ntws mus rau qhov chaw mos.
Raws li cov khoom siv bioactive uas tswj hwm ntau lub zog ntawm tes hauv lub cev, peptides ua lub luag haujlwm hauv ntau hom, suav nrog kev tswj hwm hormonal, neurotransmission, cellular kev loj hlob, thiab kev yug me nyuam.
Nyob rau hauv sib piv rau cov protein-raws li tshuaj- uas yog tus cwj pwm los ntawm complex mechanisms ntawm kev txiav txim, muaj zog phiv, thiab cov nqi siab -cov tshuaj peptide muaj ib tug tshwj xeeb txheej ntawm qhov zoo: me me molecular luj, yooj yim qauv, thiab tsis yog -immunogenicity; zoo-txhais cov txheej txheem ntawm kev txiav txim, muaj zog potency, tsis tshua muaj tshuaj noj, thiab cov kev phiv tsawg tsawg; yooj yim ntawm synthesis; yooj yim nqus los ntawm ntau txoj hauv kev, tso cai rau ntau txoj hauv kev ntawm kev tswj hwm; thiab siab hluavtaws purity, dawb los ntawm pyrogens.
Tam sim no, cov txheej txheem thev naus laus zis ua kom muaj kev sib cais ntawm ntau yam bioactive peptides los ntawm tsiaj, nroj tsuag, thiab microbial qhov chaw. Lawv lub luag haujlwm tseem ceeb hauv lub cev muaj xws li kev tiv thaiv kab mob, kev txhawb nqa kev loj hlob thiab kev loj hlob, tiv thaiv -thrombotic thiab tiv thaiv- cov teebmeem hnyav, txo cov roj cholesterol, inhibition ntawm cov kab mob thiab kab mob, tiv thaiv - mob qog noj ntshav thiab antioxidant (xws li cov dawb radical scavenging), thiab kev txhim kho ntawm lub cev nqus thiab cov pob zeb hauv av.